What is the “one protocol one consent”?
The “one protocol one consent” is an IRB approved protocol and consent that will permit the Institute of Informatics (I²) to link participant or patient genetic data that you collect to the research copy of their BJC electronic health record.
What is the purpose of the “one protocol one consent”?
The goal of this standardized protocol and consent is to reduce the burden for individual researchers wishing to make progress in genomics and precision medicine, both for their teams and the wider research community. The standardized consent incorporates best-practices language for informing participants about genomics research and potential return of research results. It has been approved by the IRB for use by all WashU/BJH researchers and clinicians. Use of this protocol and consent as a companion to the consent for your own study or in your clinical care will facilitate future analyses for your team and lead to a large campus-wide resource for long-term research in precision medicine.
How do I get started?
Researchers and clinicians interested in using the “one protocol one consent” should contact the Precision Health Navigator Tricia Salyer at firstname.lastname@example.org to be added to the study’s protocol and provided instructions for use.
The Precision Health Function aims to facilitate genomic research by making genomic resources more accessible and useful to a wide variety of researchers and providing free grant proposal services to translational genomics and precision health researchers.
ICTS UK Biobank Genomic Repository
To facilitate genomic research, the ICTS Precision Health Function has established the ICTS UK Biobank Genomic Repository. This Repository includes genomic data for 500,000 participants from the UK Biobank and has been enriched through annotation by the McDonnell Genome Institute (MGI). Using the ICTS UK Biobank Genomic Repository allows researchers to access a curated and enriched version of the data. The Repository is stored with Research Information Services (RIS) and is available for access by all approved UK Biobank users at WUSM.
If you have an approved UK Biobank project and would like access to the ICTS UK Biobank Genomic Repository for yourself and your research team, please email the Precision Health Administrator Debra Warren at email@example.com.
Details about the ICTS UKB Repository can be found in the documents below.
The database of Genotypes and Phenotypes (dbGaP) was developed to archive and distribute the data and results from studies that have investigated the interaction of genotype and phenotype in humans. Investigators can request access to dbGaP datasets for approved research projects, or they can deposit their own data.
The documents below provide detailed guidance for researchers who wish to request and submit data to dbGaP.
Contact Jenny McKenzie at firstname.lastname@example.org with any questions about these documents.
The All of Us Research Program, part of the National Institutes of Health, is building one of the largest biomedical data resources of its kind. The All of Us Research Hub stores health data from a diverse group of participants from across the United States.
There are three tiers of data available. The public tier contains aggregate data with identifiers removed. Registered tier data contains electronic health records (EHRs), wearables, surveys, and physical measurement data. Controlled tier data contains genomic data in the form of whole genome sequencing (WGS) and genotyping arrays, including previously suppressed demographic data fields from EHRs and surveys.
Approved researchers can access All of Us data and tools to conduct studies to help improve our understanding of human health.
To learn more about the All of Us Research Program and the resources available to researchers, please review the following resources: