WUSM Genomic Protocol and Consent Developed to Facilitate Genomic Research

Washington University School of Medicine Genomic Protocol and ConsentWould your research benefit from linking the genetic data you collect to electronic health records? Would you like to contribute to a shared research genomics + health records database at WashU School of Medicine? The ICTS Precision Medicine Function has developed an IRB approved protocol and consent that will permit the […]

Seeking Speakers for Precision Medicine Thursdays at Venture Café

Looking to advance your research towards commercialization? The Institute of Clinical and Translational Sciences at Washington University sponsors monthly presentations at Venture Café that bring together innovative biomedical scientists in St. Louis with the local entrepreneurial community.  The scientists give brief presentations on the significance and current state of their research, along with next steps […]

Mother’s death sets twin scientists on journey to find precision cancer therapies (Links to an external site)

Their mother’s death when they were teenagers set identical twins Obi and Malachi Griffith on a shared path to find better cancer therapies. Today, the twins, both geneticists and computational biologists at the School of Medicine, are seeking precision treatments for the disease. The Griffith Lab, driven by the twins’ independent and complementary research interests, […]

Chan Zuckerberg Grant awarded to Celeste Karch & colleagues (Links to an external site)

Celeste Karch, PhD and her collaborators, Carlos Cruchaga, PhD, Gregory Day, MD, and Oscar Harari, PhD received a Chan Zuckerberg Initiative (CZI) award to investigate the role of  microglial proteins encoded by TREM2 and MS4A in Alzheimer’s Disease and possibly other neurodegenerative disorders. In the WashU News release, Dr. Karch noted that microglia are considered immune response […]

Autism diagnosis disparities informed by genetics research

John Constantino, MD, and colleagues discussed the social implications surrounding  identifying and diagnosing black children with autism spectrum disorder in a November article in the St. Louis American.  Citing a report from the Center for Disease Control’s Autism and Developmental Disabilities Monitoring Network, they note that African American children are diagnosed later (at approximately 4 years) […]

Probiotics for children with acute gastroenteritis

A recently published article in The New England Journal of Medicine by Schnadower and colleagues reported the results from a blinded, randomized clinical trial conducted to determine if probiotics were an effective treatment for acute gastroenteritis in young children.  Dr. Phil Tarr, a pediatric gastroenterologist and precision medicine researcher was a co-author on the paper.  […]

Review of Sundaram et. al. Nature Genetics 2018

In the practice of precision medicine, the accurate filtering of common and rare missense variants of benign consequence remains an unsolved problem. Sundaram et. al. using an identity by state model attempt to infer a variants clinical importance by using their prevalence in the genomes of our close relatives, non-human primate (NHP) species. In human, […]