Holden Thorp, PhD & Robyn Klein, MD, PhD Present: Making Drugs Better by Making them Worse.

March 21, 2019
12:00 am - 12:00 am
Venture Café St. Louis, 4240 Duncan Ave, St. Louis, MO 63110

Precision Medicine Thursdays at at Venture Café
Registration available at the event.


Holden Thorp, PhD
Provost and Executive Vice Chancellor, Washington University in St. Louis

Making Drugs Better by Making them Worse – Metalloenzymes comprise a third of all enzymes and are inhibited by 10% of all marketed drugs.  Drugs that bind very strongly to metal atoms give tantalizingly high affinities, but are often toxic:  the solution lies in going on the road less traveled.

Robyn Klein, MD, PhD
Vice Provost and Associate Dean, Washington University in St. Louis

Learning from viruses: how brain inflammation may cause dementia – People who have experienced brain infections with viruses, such as West Nile virus, often develop  severe memory disorders that interfere with daily life functions.  Here I will discuss how efficient clearance of virus may lead to changes in brain structure and function.

On the third Thursday of every month , ICTS Precision Medicine hosts a session featuring WashU faculty working in translational genomics/precision medicine areas. Talks are typically oriented toward biotechnology, diagnostics, informatics, start-ups and precision interventions based on medical genomics innovations.